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Biomedical Microengineering Group

Applying micro and nanoengineering principles to understand and manipulate biology, creating new technologies for biomedical applications.

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Dr. Will Shu
Institute of Biological Chemistry, Biophysics and Bioengineering
School of Engineering and Physical Sciences
James Nasmyth Building
Heriot-Watt University
Riccarton Campus
Edinburgh, EH14 4AS;

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Selected Publications
BF 013001
Biofabrication: reappraising the definition of an evolving field (2016)
Groll J, Boland T, Blunk T, Burdick JA, Cho D, Dalton PD, Derby B, Forgacs G, Li Q, Mironov VA, Moroni L, Nakamura M, Shu W, Takeuchi S, Vozzi G, Woodfield TBF, Xu T, Yoo JJ and Malda J

Biofabrication 8 013001
BF 045012
Three-dimensional bioprinting of complex cell laden alginate hydrogel structures (2015)
Ghanizadeh Tabriz A, Hermida MA, Leslie NR and Shu W

Biofabrication 7 045012
BF 044102
Bioprinting of human pluripotent stem cells and their directed differentiation into hepatocyte-like cells for the generation of mini-livers in 3D (2015)
Faulkner-Jones A, Fyfe C, Cornelissen DJ, Gardner J, King J, Courtney A and Shu W

Biofabrication 7 044102
SNA 06036 Alogla
Micro-tweezers: Design, fabrication, simulation and testing of a pneumatically actuated micro-gripper for micromanipulation and microtactile sensing (2015)
Alogla AF, Amalou, Balmer C, Scanlan P, Shu W and Reuben RL

Sensors and Actuators A: Physical 236 pp.394-404
SNA 01036 Hammer
An optical fibre dynamic instrumented palpation sensor for the characterisation of biological tissue (2015)
Li J, Hammer SJ, Shu WM, Maier RRJ, Hand DP, Reuben RL and MacPherson WN

Sensors and Actuators A: Physical 225 pp.53-60

Quantitative diagnostics of soft tissue through viscoelastic characterization using time-based instrumented palpation (2015)
Palacio-Torralba J, Hammer S, Good DW, McNeill SA, Stewart GD, Reuben RL and Chen Y

Journal of the Mechanical Behavior of Biomedical Materials 41 pp.149-60
ACI 201411383 LC
Rapid Formation of a Supramolecular Polypeptide-DNA Hydrogel for In Situ Three-Dimensional Multilayer Bioprinting (2015)
Li C, Faulkner-Jones A, Dun AR, Jin J, Chen P, Xing Y, Yang Z, Li Z, Shu W, Liu D, Duncan RR

Angewandte Chemie - International Edition 54(13) pp.3957-61
PO 112872 PS
Tissue quality assessment using a novel direct elasticity assessment device (the e-finger): A cadaveric study of prostatectomy dissection (2014)
Good D, Khan A, Hammer S, Scanlan P, Shu W, Phipps S, Parson SH, Stewart GD, Reuben R, McNeill SA

PLoS ONE 9(11) e112872
PE 201411420 PS
A scalable, minimal contact device for the characterization of elastomer membrane deformation (2014)
Scanlan P, Hammer SJ, Shu W

Proceedia Engineering 87 pp.508-11
PE 201411702 AA
Development of a pneumatically actuated cantilever based micro- Tweezer (2014)
Alogla A, Amalou F, Scanlan P, Shu W

Proceedia Engineering 87 pp.1390-3
BB 25225 KK
Validation of a fully integrated platform and disposable microfluidic chips enabling parallel purification of genome segments for assembly (2014)
Kersaudy-Kerhoas M, Amalou F, Che A, Kelly J, Liu Y, Desmulliez MPY and Shu W

Biotechnology and Bioengineering 111(8) pp.1627-37
SPIE 2059869 Shu
Optical fibre cantilever sensor for biological application (2014)
Li J, Zhou YX, Patterson G, Shu WM, Maier RRJ, Fowler R, Hand DP and Macpherson WN

Proceedings of SPIE - The International Society for Optical Engineering 9157 91575I
NMR 3050 Hammer
Reliability of MRSI brain temperature mapping at 1.5 and 3 T (2014)
Thrippleton MJ, Parikh J, Harris BA, Hammer SJ, Semple SIK, Andrews PJD, Wardlaw JM and Marshall I

NMR in Biomedicine 27(2) pp.183-190
BJU 12236 Hammer
Elasticity as a biomarker for prostate cancer: A systematic review (2014)
Good DW, Stewart GD, Hammer S, Scanlan P, Shu W, Phipps S, Reuben R and McNeill AS

BJU International 113(4) pp.523-534
SNA 8150 Alogla
A scalable syringe-actuated microgripper for biological manipulation (2013)
Alogla A, Scanlan P, Shu W and Reuben RL

Sensors and Actuators A: Physical 202 pp.135-9
BF 015013
Development of a valve-based cell printer for the formation of human embryonic stem cell spheroid aggregates (2013)
Faulkner-Jones A, Greenhough S, King JA, Gardner J, Courtney A and Shu W

Biofabrication 5 015013
SNB 1016 012 Liu
Label-free and real-time monitoring of yeast cell growth by the bending of polymer microcantilever biosensors (2013)
Liu Y, Schweizer LM, Wang W, Reuben RL, Schweizer M and Shu W

Sensors and Actuators B: Chemical 178 pp.621-6
PE 3512 Alogla1
A Scalable Syringe-Actuated Microgripper for Biological Manipulation (2012)
Alogla A, Scanlan P, Shu W and Reuben RL

Procedia Engineering 47 pp.882-5 10.1016/j.proeng.2012.09.288
PE 43500 Shu1
Design, Fabrication and Test of a Polymer Air Driven Microturbine for Micropower Generation (2012)
Dettelbacher C, Früh WG and Shu W

Procedia Engineering 47 pp.877-81
NP 02FA11 Faulkner-Jones1
Biological cell printing technologies (2012)
Faulkner A and Shu W

Nanotechnology Perceptions 8(1) pp.35-57
Microcantilever Biosensors: Probing Biomolecular Interactions at the Nanoscale (2011)
Lui D and Shu W

Current Organic Chemistry 15(4) pp.477-85
BB 1516 Shu1
Highly Specific Label-free Protein Detection from Lysed Cells using Internally Referenced Microcantilever Sensors (2008)
Shu W, Laurenson S, Knowles TPJ, Ferrigno PK and Seshia AA

Biosensors & Bioelectronics 24(2) pp.233-237
NT 384007 Shu1
Label-free Detection of Amyloid Growth using Microcantilever Sensors (2008)
Knowles T, Shu W , Hubert F, Lang HP, Dobson CM and Welland ME

Nanotechnology 19 384007
NL 073157 Shu1
Polyelectrolyte Brush Amplified Electroactuation of Microcantilevers (2008)
Zhou F, Biesheuvel P, Choi EY, Shu W, Poetes R, Steiner U and Huck WT

Nano Letters 8(92) pp.725-30
PNAS 10016 Shu1
Kinetics and Thermodynamics of Amyloid Formation from Direct Measurements of Fluctuations in Fibril Mass (2007)
Knowles TPJ, Shu W, Devlin GL, Meehan S, Auer S, Dobson CM and Welland ME

Proceedings of the National Academy of Sciences 104(24) pp.10016-21
BB 4155 Shu1
Investigation of Biotin-Streptavidin Binding Interactions using Microcantilever Sensors (2006)
Shu W, Laue ED and Seshia AA

Biosensors & Bioelectronics 22(9) pp.2003-9
JA 060649 Shu1
Highly Reversible and Multi-Stage Cantilever Actuation Driven by Polyelectrolyte Brushes (2006)
Zhou F, Shu W, Welland ME and Huck WT

Journal of the American Chemical Society 128(16) pp.5326-7
MEMS 23450 Shu1
Microheated Substrates for Patterning Cells and Controlling Development (2005)
Shu W, Everett WN, Zhang QX, Liu MH, Trigg A, Spearing SM, Wang S, Sue HJ and Moran PM

IEEE/ASME Journal of Microelectromechanical Systems 14(5) pp.924-34
JA 0554514 Shu1
DNA Molecular Motor Driven Micromechanical Cantilever Arrays (2005)
Shu W, Liu D, Watari M, Riener CK, Strunz T, Welland ME, Balasubramanian S and McKendry RA

Journal of the American Chemical Society 127(48) pp.17054-60